Skip to content
Meru Staging

    Meru Staging

    Meru Staging
    With modularity, interoperability, and openness as guiding principles, Next Generation Library Publishing (NGLP), is developing library publishing resources that combine the values alignment of open source software with the convenience of turnkey publishing and repository solutions. The project is simultaneously building interoperable software components tailored to the unique needs of library publishers and designing business and governance models, values-based assessment frameworks, and pilot implementations that will bring our code to life. This is a test instance undergoing active development.
    Meru Staging
    Explore
    • Home
    • Communities
    • Admin

    © Copyright 2022 Meru

    • /
    • Test Community with Units/
    • UC Merced Previously Published Works/

    Hongqiao Zhang, Kelvin JA Davies, Henry Jay Forman November 1, 2015
    Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety of age-related pathologies. In aging, oxidant production from several sources is increased, whereas antioxidant enzymes, the primary lines of defense, are decreased. Repair systems, including the proteasomal degradation of damaged proteins, also decline. Importantly, the adaptive response to oxidative stress declines with aging. Nrf2/EpRE signaling regulates the basal and inducible expression of many antioxidant enzymes and the proteasome. Nrf2/EpRE activity is regulated at several levels, including transcription, posttranslation, and interactions with other proteins. This review summarizes current studies on age-related impairment of Nrf2/EpRE function and discusses the changes in Nrf2 regulatory mechanisms with aging.
    Download PDF
    148 Views
    94 Downloads
    Skip to content
    • Full Text
    • Metadata
    • Files
    • Contributors
    • Metrics

    contributors

    • Hongqiao Zhang

      Author

    • Kelvin JA Davies

      Author

    • Henry Jay Forman

      Author