Molybdenum disulfide (MoS2) is one of the most broadly utilized solid lubricants with a wide range of applications, including but not limited to those in the aerospace/space industry. Here we present a focused review of solid lubrication with MoS2 by highlighting its structure, synthesis, applications and the fundamental mechanisms underlying its lubricative properties, together with a discussion of their environmental and temperature dependence. The review also includes an extensive overview of the structure and tribological properties of doped MoS2, followed by a discussion of potential future research directions.