Underpinning genomic principles are dening feature in every physiologic and pathologic process. Through advances in metabolomics, systems biologists can now track the dynamic interactions of the metabolome with the epigenome, genome, transcriptome and proteome. Understanding of cross talk between genomic, epigenomic and structural changes at biophysical scale on cellular metabolism is still in its infancy. Using Next-Gen Sequencing data in tandem with biophysical approaches, metabolism was found to play an important role in cellular proliferation, differentiation, metastasis. Mutation, methylation and gene expression level changes at genomic and epigenomic scale orchestrate pathway perturbations crucial for oncogenesis and metastasis. These results show understanding genomic

and epigenomic machinery can provide important insights into cellular processes vital for growth and development in tumor cells. Increased attention to how genomic processes support transformational changes necessary for a cancer cell will allow for more precise engineering of biological function and the identification of targeted therapies.